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Research Associate (Postdoctoral) - 300714
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| Location: Rockville, MD | Center: CARB | | # of Positions Available: 1 | Job Type: Full-Time |
| Category Status: Faculty | Date Posted: 9/17/2009 | | Salary: Open | Job Category: Faculty & Research |
| Description |
The hypovirus/C. parasitica system has proven to be uniquely suited for developing the concept of engineering viruses for the purposes of understanding and modulating fungal pathogenesis. A very robust DNA transformation system is available for C. parasitica allowing disruption, silencing or over-expression of fungal host genes. Infectious cDNA clones have been constructed for several hypovirus RNA genomes, providing one of the very few eucaryotic systems for which both a virus and its host can be genetically manipulated with ease. Studies will take advantage of recently developed DNA microarray capabilities to gain deeper insight into virus-host interactions and test the fundamental hypothesis that RNA silencing in fungi evolved as an antiviral defense mechanism. Combined basic and technical advances are providing new opportunities for broadening the potential application of hypoviruses for purposes of understanding and controlling fungal pathogenesis. (http://www.umbi.umd.edu/cbr/faculty-directory/nuss/index.php)
Duties Include:
-Investigate the molecular biology of viruses (Hypoviruses) that reduce virulence and alter phenotype of the chestnut blight fungus Cryphonectria parasitica;
-Assist in the preparation of manuscripts reporting research results.
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| Qualifications |
REQUIRED:
Ph.D. in areas of molecular virology and/or molecular mycology or related areas; good technical, writing and interpersonal skills.
Bioinformatics experience would be considered a plus.
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